Principle Scientist - Discovery Biomarker

Company: Amgen
Location: South San Francisco
Posted on: March 7, 2026

Job Description:

Join Amgens Mission of Serving Patients At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do. Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career. PrincipalScientist - Discovery Biomarkers What you will do Letsdo this.Letschange the world. In this vitalroleyou will focus on the discovery of biomarkers to support the progression of therapeutic candidates from discovery to early clinical development. The Amgen Discovery Biomarkers group is looking for an innovative PrincipalScientist, dedicated to biomarker discovery in the areas of inflammationand rare disease. This Principal Scientist will work cross-functionally and interact closely with both thedevelopment andresearch groups. Key Responsibilities Develop comprehensive disease area expertise for key indications within the inflammation therapeutic area Support strategic initiatives by providing deep scientific knowledge of inflammatory pathways and mechanisms Stay current with emerging research and therapeutic approaches in inflammatory diseases Identify, evaluate, and prioritize relevant target engagement biomarkers for inflammatory conditions Define quantitative thresholds for biomarker efficacy and clinical relevance Integrate exposure data with pharmacodynamic modulation information to create comprehensive temporal profiles Design and execute biomarker discovery strategies across multiple programs using real-world, clinical, and preclinical data Demonstrate exceptional thoroughness and expertise when conducting complex immunology-related assays Generate high-quality pharmacodynamic data to inform clinical development decisions Assess population heterogeneity through sophisticated biomarker measurements Support companion diagnostic test development when required for targeted therapies Evaluate the applicability and relevance of preclinical findings from model systems to human contexts Bridge the gap between laboratory discoveries and clinical applications Support translational biomarker activities for therapeutic assets, including participation in investigator meetings and advisory boards Collaborate on investigator-sponsored studies for correlative biomarker research alongside Clinical Biomarker leads Work effectively in a highly matrixed environment to drive scientific and technical innovation Collaborate with cross-functional teams in Inflammatory Diseases, Clinical Biomarker & Diagnostics, Therapeutic Discovery, Human Genetics, and Computational Biology Mentor laboratory scientists to ensure generation of high-quality, reliable experimental data Provide scientific leadership and guidance to junior team members What we expect of you We are all different, yet we all use our unique contributions to serve patients. The principal scientist we seek is a professional with these qualifications. Basic Qualifications: Doctorate degree PhD, PharmD, MD with relevant postdoctoral experience and 2 years of Discovery Biomarkers experience OR Masters degree and 5 years of Discovery Biomarkers experience OR Bachelors degree and 7 years of Discovery Biomarkers experience Preferred Qualifications: PhD or MDPhD, with postdoctoral training andindustryexperience in the fields ofimmunology (must have), cell and molecular biology, or biochemistry. Biomarker Clinical Development experience is preferred. Demonstratedtrack recordof independent critical thinking and scientific achievement in the areas of cell and molecular biology and biochemistry asdemonstratedby multiple high impact publications Demonstrated experience in leading independent research and/or drug development Experience with implementing multiple technology platforms Strong verbal and written communication skills.Ability to collaborate and troubleshoot to solve problems Experience working in teams, managingscientistsand consistently delivering results What you can expect of us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include: A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan Stock-based long-term incentives Award-winning time-off plans Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies. Apply now and make a lasting impact with the Amgen team. careers.amgen.com In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information. Application deadline Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Sponsorship Sponsorship for this role is not guaranteed. As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease. Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Keywords: Amgen, Rancho Cordova , Principle Scientist - Discovery Biomarker, Science, Research & Development , South San Francisco, California